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The city is enormous and the traffic is severe, so where you sleep decides how much of the day you spend in a car.
The decision that matters
Roma and Condesa — leafy, walkable, safe, the best restaurants, and the standard recommendation. Also the most expensive central option.
Centro Histórico — the colonial core, best for the main sights and for value, noisy, and largely empty after nine at night.
Juárez and Cuauhtémoc — between the two, on Reforma, good value.
Polanco — the luxury end, next to Chapultepec, and rather sterile.
Coyoacán and San Ángel — the southern villages, quieter and more Mexican, and 45 to 60 minutes from the Centro.
The full comparison is in where to stay in Mexico City.
Before booking
Whether the building post-dates 1985. The seismic code changed completely after that earthquake, and modern construction is markedly safer. A hotel should be able to tell you its punto de reunión.
An interior room in the Centro and Zona Rosa, where street noise is constant.
A lift, since many converted houses do not have one — and at 2,240 metres, three flights on the first day is not nothing.
Purified water — universal, but ask where it is.
A note worth making
Roma and Condesa have seen rents rise sharply since 2020, driven partly by short-term rentals and an influx of remote workers, and there has been organised protest about the displacement.
Staying in a hotel, or choosing Juárez, the Centro or Coyoacán, is a reasonable response if that matters to you.
When it costs most
Day of the Dead, late October into early November — book months ahead. Christmas and Semana Santa both fill.
June to September, the rainy season, is cheapest and is much less of a problem than it sounds.